Evidence reference only. Not medical advice, not a dosing guide, and not a recommendation to use any drug.
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Effect Domains

Neutral research domains. These labels organize evidence; they are not promises about outcomes.

safety-other

GLP-1-based therapies, multi-agent, Semaglutide, Tirzepatide

129 findings Open domain ->

pharmacology

Semaglutide, Tirzepatide, GLP-1-based therapies, multi-agent

67 findings Open domain ->

weight-loss

Dulaglutide, Orforglipron, CagriSema

55 findings Open domain ->

body-composition

GLP-1-based therapies, multi-agent, Retatrutide, Liraglutide

44 findings Open domain ->

Stomach and gut

GLP-1-based therapies, multi-agent, Orforglipron, CagriSema

36 findings Open domain ->

appetite-intake

Retatrutide, Semaglutide, Liraglutide

32 findings Open domain ->

Specific groups of people

Semaglutide, Tirzepatide, GLP-1-based therapies, multi-agent

32 findings Open domain ->

glycaemic

Dulaglutide, Retatrutide, CagriSema

31 findings Open domain ->

Liver and MASH

Multi-agent review synthesis, Cotadutide, Efinopegdutide

23 findings Open domain ->

Heart and circulation

Semaglutide, Dulaglutide, Retatrutide

22 findings Open domain ->

renal

Native glucagon physiology, Dulaglutide, Tirzepatide

22 findings Open domain ->

Brain and mood

GLP-1-based therapies, multi-agent, Exenatide, Semaglutide

21 findings Open domain ->

Head-to-head comparisons

Tirzepatide, Orforglipron, CagriSema

21 findings Open domain ->

insulin-beta-cell

Retatrutide, Tirzepatide and semaglutide comparison, Exenatide

20 findings Open domain ->

Heart rate

Native glucagon physiology, Cotadutide, Retatrutide

18 findings Open domain ->

energy-expenditure-thermogenesis

Tirzepatide, Semaglutide, Retatrutide

16 findings Open domain ->

lipids-lipoprotein

Retatrutide, Pemvidutide, Survodutide

14 findings Open domain ->

Heart failure

Liraglutide, Semaglutide, Tirzepatide

12 findings Open domain ->

weight-maintenance-regain

GLP-1-based therapies, multi-agent, Semaglutide, Tirzepatide

11 findings Open domain ->

blood-pressure

CagriSema, Survodutide, Mazdutide

10 findings Open domain ->

Sleep apnoea

Tirzepatide, GLP-1-based therapies, multi-agent, Liraglutide

9 findings Open domain ->

Cost and sticking with it

GLP-1-based therapies, multi-agent, Tirzepatide, Semaglutide

6 findings Open domain ->