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Weight-loss Physiology (drug-agnostic)

MARKETED

weight-loss physiology (drug-agnostic mechanism)

2
graded findings
1
effect domains
Evidence spread
High evidence 0Moderate evidence 1Low evidence 1Very low evidence 0

Weight-loss Physiology (drug-agnostic) is shown as a marketed evidence record where applicable. Findings describe observed research and regulatory records; they do not provide treatment advice.

Thin or bounded evidence here means uncertainty remains visible. It is not evidence that an effect has been ruled out.
Weight-loss Physiology (drug-agnostic) MARKETED
Maintenance and regain Increase
Moderate evidence

MECHANISM (set-point / why regain happens): one year after diet-induced weight loss, circulating appetite-regulating hormones remained shifted in a direction that...

Sumithran P, Prendergast LA, Delbridge E et al., N Engl J Med, 2011 Source
Full findingMECHANISM (set-point / why regain happens): one year after diet-induced weight loss, circulating appetite-regulating hormones remained shifted in a direction that favours regain (ghrelin up; leptin/PYY/CCK/insulin down) and had NOT reverted, with persistently increased hunger. The foundational human evidence that the body defends a higher weight via a durable orexigenic state.
PopulationSumithran/Proietto (NCT00870259): N=50 overweight/obese adults without diabetes; 10-week very-low-energy diet; hormones at baseline, 10 wk, 62 wk.
Fundingacademic/government - Australian NHMRC and others (not industry)
Scope limitssmall sample (N~50)
Comparatorswithin-subject baseline
Weight-loss Physiology (drug-agnostic) MARKETED
Maintenance and regain Decrease
Low evidence

MECHANISM (adaptive thermogenesis / set-point): six years after large weight loss, resting metabolic rate remained suppressed below baseline and metabolic adaptation...

Fothergill E, Guo J, Howard L et al., Obesity (Silver Spring), 2016 Source
Full findingMECHANISM (adaptive thermogenesis / set-point): six years after large weight loss, resting metabolic rate remained suppressed below baseline and metabolic adaptation persisted DESPITE substantial regain - direct human DXA-plus-calorimetry evidence that adaptive thermogenesis is durable and proportional to ongoing weight suppression.
PopulationFothergill/Hall ('Biggest Loser'): N=14 of 16 competitors; DXA + indirect calorimetry at baseline, 30 wk, 6 yr.
Fundingacademic/independent analysis (manufacturer not study sponsor; per-study COI not individually audited)
Scope limitsanimal data; human relevance uncertain; small sample (N~14)
Comparatorswithin-subject baseline