Evidence reference only. Not medical advice, not a dosing guide, and not a recommendation to use any drug.
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Lixisenatide

WITHDRAWN

Exendin-4-based GLP-1 receptor agonist

3
graded results
0
ongoing records
3
effect domains
Evidence spread
High evidence 2Moderate evidence 1Low evidence 0Very low evidence 0

Lixisenatide has a withdrawn status in the scoped regulatory record below. Results describe observations and do not provide treatment advice.

Dated status sources

WITHDRAWN European Union; Type 2 diabetes; Subcutaneous injection; as of 2026-07-13. European Medicines Agency

The grade rates how strong the evidence is, not how good or safe the drug is. A low or very-low grade means the evidence is thin, not that an effect is harmful or ruled out.

Thin or bounded evidence here means uncertainty remains visible. It is not evidence that an effect has been ruled out.
Lixisenatide WITHDRAWN
Heart and circulation No change
High evidence

In T2D after a recent acute coronary syndrome, lixisenatide was non-inferior but NOT superior to placebo for the CV composite: a fully NEUTRAL CV outcome.

Pfeffer MA et al. (ELIXA), NEJM, 2015 Source
PopulationELIXA: N=6068; T2D with ACS within 180 days; double-blind placebo-controlled RCT; median 25 months.
Fundingindustry - Sanofi (disclosed in publication)
Comparatorsplacebo
Thin or bounded evidence here means uncertainty remains visible. It is not evidence that an effect has been ruled out.
Lixisenatide WITHDRAWN
Brain and mood Decrease
Moderate evidence

NEURODEGENERATION (Parkinson's) - the middle pole: in the LIXIPARK phase-2 trial in early Parkinson's, lixisenatide produced less motor-disability progression than...

Meissner WG, Remy P, Giordana C et al., N Engl J Med, 2024 (LIXIPARK) Source
Full findingNEURODEGENERATION (Parkinson's) - the middle pole: in the LIXIPARK phase-2 trial in early Parkinson's, lixisenatide produced less motor-disability progression than placebo at 12 months (~3-point MDS-UPDRS difference), but the effect attenuated after washout and came with substantial GI side effects.
PopulationLIXIPARK (NCT03439943): N=156 early PD (<3 years); double-blind RCT; daily s.c. lixisenatide, 12 months + 2-month washout.
Fundingacademic / non-commercial (LIXIPARK; French PHRC government programme; disclosed)
Comparatorsplacebo
Thin or bounded evidence here means uncertainty remains visible. It is not evidence that an effect has been ruled out.
Lixisenatide WITHDRAWN
glycaemic Decrease
High evidence

In the GetGoal phase 3 programme lixisenatide reduced HbA1c by approx 0.5-0.9%; in the ELIXA cardiovascular outcomes trial it was MACE-neutral vs placebo in T2D after...

Pfeffer MA et al., NEJM 2015 (ELIXA) Source
Full findingIn the GetGoal phase 3 programme lixisenatide reduced HbA1c by approx 0.5-0.9%; in the ELIXA cardiovascular outcomes trial it was MACE-neutral vs placebo in T2D after acute coronary syndrome.
PopulationGetGoal: ~5000 T2D across settings. ELIXA: 6068 T2D within 70 days of ACS, lixisenatide vs placebo, median ~2.1 years
Fundingindustry - Sanofi
Comparatorsplacebo